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Preexisting psychiatric conditions may be exacerbated by corticosteroid use. Septic arthritis May occur as a complication to parenteral therapy; institute appropriate antimicrobial therapy as required. Cardiovascular disease Use with caution in patients with heart failure HF and or hypertension; use has been associated with fluid retention, electrolyte disturbances, and hypertension. Use with caution following acute myocardial infarction MI ; corticosteroids have been associated with myocardial rupture, dumbbell skullcrusher form.
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